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New Era Manchester United

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But Alzheimer's experts have been through this dance before, and they say they're not holding their breaths that the new drugs will make it to patients.

In the past year alone, three closely watched new agents failed in late stage clinical trials. In May, a Massachusetts pharmaceutical company announced it would close after its experimental Alzheimer's drug ran into unexpected safety problems. In June, Eli Lilly stopped a study of a different BACE inhibitor when patients who were taking the drug showed signs of liver problems.

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The second drug is thought to reduce damaging inflammation. Patients with mild mental impairment who took the drug for over a year saw significant improvements in some measures of memory and thinking.

One drug, called a BACE inhibitor, has been in development for more than 10 years. In very early tests, it dramatically reduced levels of beta amyloid, a sticky protein that forms plaques in the brains of Alzheimer's patients.

New Era Manchester United

New Era Manchester United

"In the Alzheimer's field, it Brooklyn Nets Hat

New Era Manchester United

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Those disappointments come on top of years of trying New Era Manchester United and failing at other promising approaches. The plaques that clog the brains of Alzheimer's patients seem to be accelerated by high cholesterol in the blood. So researchers tried cholesterol lowering drugs in Alzheimer's patients. That didn't work. Doctors noticed that the brains of people with Alzheimer's are very inflamed, so researchers mounted large trials to test over the counter anti inflammatory medications against memory loss. They were of no help.

Normally, those reports would be cause for optimism in a disease that affects 5 million people and currently has no effective treatments.

So far, the search for a drug that might slow or stop the relentless march of Alzheimer's disease through the brain has proved fruitless.

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The results of the studies, both sponsored by companies hoping to market the medications, are scheduled to be presented Sunday at the Alzheimer's Association International Atlanta Braves Hats New Era

Rosenberg said he probably would attend the presentation of the latest trials because, as he put it, "This is way new stuff."

2 New Alzheimer's Drugs Show Promise in Early Studies

Conference, in Boston.

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can be said to be zero, because we haven't a new drug in 10 years," said Rosenberg, who was not involved in the studies.

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"It's like that movie '27 Dresses,'" said Dr. Paul Rosenberg, an associate professor of psychiatry and behavioral sciences at Johns Hopkins University School of Medicine, in Baltimore. "We've been bridesmaids in this field so many times."

New Era Manchester United

New Era Manchester United

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